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Anjana Sukhani put her academic pursuits behind to pursue acting.
During the early years of her career, she was cast in a television
advertisement for Cadbury Dairy Milk chocolates with the Bollywood
superstar Amitabh Bachchan.She was also noted for her performance in the
remixed Hindi music video for the song Ghar Jayegi. Even though she
does not have a film industry related background, she has figured in
sizeable roles like in the 2007 multi-starrer blockbuster film
Salaam-e-Ishq, following which she starred in Golmaal Returns, a sequel
to the 2006 hit film Golmaal. Her other releases were Jai Veeru, Jashnn
and her Kannada debut film Maleyali Jotheyali alongside Ganesh and
Yuvika Chaudhary. She has been cast in Tollywood actor Ravi Teja's film Don Seenu marking her entry into tollywood more.